PEMBROKE, N.Y. — A New York highway is closed for what is being called a “serious mass casualty” event after a tour bus crashed.

The crash happened about 30 miles northeast of Buffalo, New York, in the area near Pembroke on the New York State Thruway, CBS News reported.

Initially, CBS News and outlets reported that the crash involved a bus and a tractor-trailer, but later updates from the state police said that the bus did not hit another vehicle.

“The bus was traveling eastbound right before the Pembroke exit and for unknown reasons the vehicle lost control, went into the median, overcorrected and ended up in the ditch, which would be on the right side of the roadway,” Trooper James O’Callahan, New York State Police spokesperson, said, according to the AP.

The New York Times said there were multiple injuries and Mercy Flight, which provides air transport to hospitals, made several trips to the scene and medical facilities.

Two children and two adults have been flown as of 2 p.m. ET, the newspaper reported.

Fox News reported that there may be up to 52 patients, with some ejected from the bus and others trapped.

The Associated Press reported that there were deaths in the crash, but did not give exact numbers.

“At this time, we have multiple fatalities, multiple entrapments and multiple injuries,” O’Callahan said, according to the AP.

WIVB reported that state police said at least one child was killed and that most passengers were not wearing their seatbelts.

The bus driver was alive, WIVB reported.

The bus was en route from Niagara Falls to New York City and was carrying people of Indian, Chinese and Philippine nationalities and translators were requested, the AP reported.

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